2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107726A
    BIBP3226 159013-54-4 98%
    BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect.
    BIBP3226
  • HY-108425B
    (Rac)-AMG8379 1641574-26-6 98%
    (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .
    (Rac)-AMG8379
  • HY-110281R
    Dehydroascorbic acid (Standard) 490-83-5
    Dehydroascorbic acid (Standard) is the analytical standard of Dehydroascorbic acid. This product is intended for research and analytical applications. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.
    Dehydroascorbic acid (Standard)
  • HY-111191A
    (R)-ONO-2952 2988224-39-9 99.97%
    (R)-ONO-2952 is a R-enantiomer of ONO-2952. ONO-2952 is a potent, selective and orally active TSPO antagonist with Kis of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes.
    (R)-ONO-2952
  • HY-116808B
    TPN729MA 1422955-52-9 99.45%
    TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729MA affects erectile function and it can be used for the research of erectile dysfunction.
    TPN729MA
  • HY-123534A
    CYT-1010 hydrochloride 1161517-81-2 98%
    CYT-1010 hydrochloride is a mu-opioid receptor agonist extracted from patent WO2013173730A2, with EC50s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively.
    CYT-1010 hydrochloride
  • HY-132831A
    Selnoflast calcium 2887416-19-3 98%
    Selnoflast calcium (RO7486967 calcium), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast calcium is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast calcium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease.
    Selnoflast calcium
  • HY-132831B
    Selnoflast potassium 98%
    Selnoflast potassium (RO7486967 potassium), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast potassium is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast potassium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease.
    Selnoflast potassium
  • HY-136109B
    (Rac)-SEP-363856 1310426-29-9 98%
    (Rac)-SEP-363856 is the racemate of SEP-363856. SEP-363856（SEP-856）, an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 （SEP-856） has the potential for the treatment of schizophrenia.
    (Rac)-SEP-363856
  • HY-160440A
    VU6021625 2803696-99-1 98%
    VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC50 value of 0.44 nM, 57 nM for human M4 and rat M4, respectively.
    VU6021625
  • HY-U00096A
    Ansofaxine 916918-80-4 98%
    Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for the research of depression.
    Ansofaxine
  • HY-W010410R
    Oct-1-en-3-ol (Standard) 3391-86-4
    Methyl ricinoleate (Standard) is the analytical standard of Methyl ricinoleate. This product is intended for research and analytical applications. Methyl ricinoleate is a compound belonging to the group of fatty acid methyl esters. It is derived from ricinoleic acid, a monounsaturated omega-9 fatty acid found in castor oil. Methyl ricinoleate is often used as a reference compound for the analysis of fatty acid methyl esters by gas chromatography. It has also been investigated for its potential use as a biofuel and as an ingredient in the production of biodegradable plastics and surfactants.
    Oct-1-en-3-ol (Standard)
  • HY-W015546R
    β-N-methylamino-L-alanine hydrochloride (Standard) 16012-55-8
    Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM. Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator.
    β-N-methylamino-L-alanine hydrochloride (Standard)
  • HY-W040146S
    Propionylpromazine-d6 hydrochloride 1262770-67-1 99.78%
    Propionylpromazine-d6 (hydrochloride) is the deuterium labeled Propionylpromazine hydrochloride. Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease.
    Propionylpromazine-d6 hydrochloride
  • HY-P2461
    MOG (89-113), human 218291-36-2 98%
    MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.
    MOG (89-113), human
  • HY-P2471
    Neurogranin (48-76), mouse 98%
    Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca2+-CaM) pathway.
    Neurogranin (48-76), mouse
  • HY-P2473
    Neurogranin (48-76), human 98%
    Neurogranin (48-76), human is a dominant endogenous peptide in Alzheimer's disease (AD) brain tissue. Neurogranin (48-76) is a potential biomarker for synaptic function in AD.
    Neurogranin (48-76), human
  • HY-P2549
    Biotin-β-Amyloid (1-40) 183906-14-1 98%
    Biotin-β-Amyloid (1-40) is a N-terminal-labelled biotinylated amyloid-β-(1-40) peptide.
    Biotin-β-Amyloid (1-40)
  • HY-P2551
    Biotin-β-Amyloid (17-40) 98%
    Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-β(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP).
    Biotin-β-Amyloid (17-40)
  • HY-110223
    Atomoxetine-d3 hydrochloride 1217776-38-9 98%
    Atomoxetine-d3 hydrochloride is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
    Atomoxetine-d3 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity